Скачать или смотреть Synthetic Chemistry bioinorganic chem 1 - (1.13)

The lecture covers three main classes of bioinorganic systems:
-1. Hydrolysis and Zinc Enzymes: A look at Carbonic Anhydrase and how zinc acts as a Lewis acid to create nucleophilic hydroxide (OH− ) for CO.
-2 hydration. It also touches on acid phosphatases that use Fe3+.
-3 Electron Transfer and Marcus Theory: Discussion on the movement of electrons through proteins like iron-sulfur clusters, blue copper proteins, and cytochromes. The lecture explains Marcus Theory, emphasizing how reorganization energy affects electron transfer rates.
-4 Oxygen Transport: Comparisons between hemoglobin (iron/heme), hemocyanin (copper), and hemerythrin (non-heme iron). A fascinating case study of the "Icefish" with colorless blood is used to explain the necessity of metal-based transporters in most environments.

0:17 - Overview of bioinorganic chemistry lessons and introduction to bioinorganic systems
2:10 - Discussion of hydrolysis and the role of carbonic anhydrase in CO2 fixation
6:04 - Photosynthesis and reduction of CO2 to carbohydrates, role of metal centers in redox reactions
14:04 - Redox-active metal centers in nature: iron, manganese, nickel, cobalt, and zinc enzymes
18:41 - Structure and function of zinc in carbonic anhydrase and hydrolysis reactions
24:18 - Biological importance of carbonic anhydrase and fast catalysis of CO2 hydration
41:15 - Electron transfer metals and importance of redox potential in biological systems
48:01 - Iron-sulfur clusters, blue copper proteins, and cytochromes in electron transfer
49:08 - Introduction to Marcus theory for electron transfer rates
56:00 - Explanation of electron transfer mechanism and reorganization energy in Marcus theory

[01:03:18] Innersphere vs. Outersphere reorganization; the role of the protein "pocket" in stabilizing reaction sites.

Oxygen Transport and Biological Cases
[01:22:09] Three systems for oxygen transport: Hemoglobin (Iron), Hemocyanin (Copper), and Hemerythrin (Non-heme Iron).

[01:23:03] Hemocyanin: "Blue blood" used by spiders and mollusks, transporting oxygen as peroxide.

[01:24:26] Hemerythrin: Asymmetrical di-iron system in certain sea animals.

[01:30:19] The Antarctic Icefish: Explanation of how it survives with colorless blood (no metal transporters) due to high oxygen solubility in cold water and massive blood volume.

Structure and Function

[01:15:20] Aconitase: An iron-sulfur cluster that functions both as an enzyme (Citrate cycle) and an iron metabolism sensor.

[01:40:17] Sodium pumps and electric impulses: Using the Nernst equation to calculate potential shifts in cell membranes.
60:19 - Relationship between geometry changes and electron transfer rates in metal centers
89:01 - Role of sulfur in iron-sulfur clusters and its evolutionary significance
90:02 - Case study: Antarctic blackfin ice fish lacking oxygen-transporting metals
97:00 - Importance of metal binding for efficient oxygen transport in blood and analogy to gas storage