PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking

Описание к видео PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking

Erwan Bezard and Laurent Groc of the University of Bordeaux discuss the effects of the post-synaptic density protein PSD-95 on the development of levodopa-induced dyskinesia. Highlights:

L-DOPA-induced dyskinesia (LID) is a major side effect of dopamine replacement therapy for Parkinson's disease.

LID is associated with changes in D1 dopamine receptor (D1R) interactions at the striatal synapses.

Using rat and macaque models, Bezard, Groc, and colleagues demonstrated that the synaptic density protein PSD-95 alters the trafficking of D1R to the synapse.

Loss of PSD-95 in the striatum reduces the development and severity of LID.

Article: http://www.jci.org/articles/view/59426

Комментарии

Информация по комментариям в разработке

Похожие видео