NHLBI ICTR SHORT VIDEO #4: FUTILITY STOPPING

When evidence emerges that an ongoing clinical trial is unlikely to meet its objective, a futility rule terminating the trial protects patients and saves resources. Patients are spared potential side effects of a ineffective treatment and may enroll in more promising trials, while sponsors can save 20-50% or more of the cost of going to the maximal sample size. In this short video Dr. Anna McGlothlin will present examples of futility rules, examine the trade-off between sample size savings and power, and illustrate graphical tools for exploring and selecting rules in practice.

This video has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract No.HHSN268201800008I.

Visit the ICTR website at www.innovativeclinicaltrial.org for more videos and information!