Extracellular vesicles as a tool for diagnostics and therapeutics: insights and challenges [WEBINAR]

For more information, visit https://www.miltenyibiotec.com/exosome Extracellular vesicles (EVs) are intercellular communication vehicles with high clinical relevance as potential disease biomarkers for diagnostics and as therapeutic agents in targeted cargo delivery. However, due to their heterogeneity in size and composition, EVs are difficult to isolate and classify. In this roundtable, Stefan Wild (Senior Scientist R&D, Miltenyi Biotec) moderates the discussion about research progress and challenges on the clinical application of extracellular vesicles (EVs). Three leading experts in the field, Tony De Fougerolles (CEO, Evox Therapeutics), Joana Correia (CEO, Exogenus Therapeutics) and Joshua Welsh (Research Fellow, NIH) share their experience on the technical limitations of EV detection, EV engineering methodologies, advantages of EVs in comparison to cellular therapy, and the imperative need for standardized EV analytics.

Due to their physical and biochemical properties, EVs are ideal biological vehicles, as they show low immunogenicity and the ability to cross biological barriers. Moreover, the potential for targeted delivery to specific tissues or cells combined with the advancements in EV engineering methodologies, opens endless possibilities for EV applications in disease treatment. While the interest in EV research has been progressively increasing, technology that allows for precise and reproducible detection and characterization of EVs will be essential for the implementation of their promising clinical applications.

A reliable and robust method allowing analysis of multiple markers is required to study the surface signature of EVs and identify potential subtypes with clinical relevance. To provide an easy and fast screening of EV surface proteins, we developed the MACSPlex EV Kit IO, a multiplex bead-based flow cytometry assay. The combination of 39 different MACSPlex EV Capture Beads allows for the detection and analysis of 37 markers plus 2 isotype controls in parallel, by standard flow cytometry. MACSPlex EV Kit IO provides you with the possibility to analyze established EV detection markers in combination with EV epitopes that are specific for the immuno-oncology (IO) field of research.


Miltenyi Biotec is a global provider of products and services that empower biomedical discovery and advance cellular therapy. Our innovative tools support research at every level, from basic research to translational research to clinical application. This integrated portfolio enables scientists and clinicians to obtain, analyze, and utilize the cell. Our technologies enable solutions for cellular research, cell therapy, cell manufacturing, and imaging. Our 30 years of expertise spans research areas including immunology, stem cell biology, neuroscience, and cancer, and clinical research areas like hematology, graft engineering, and apheresis. In our commitment to the scientific community, we also offer comprehensive scientific support, consultation, and expert training. Today, Miltenyi Biotec has more than 3,000 employees in 28 countries – all dedicated to helping researchers and clinicians around the world make a greater impact on science and health.