The Warburg Effect - How cancer cells use aerobic glycolysis to survive

A short summary about how cancer cells induce aerobic glycolysis and the proposed functions of such.

Sources:

Berg, J., Tymozco, T., Gatto, G., & Stryer, L. (2019). Biochemistry (9th ed.). Macmillan International, Higher Education.

End-of-life care. National Cancer Institute. (2021). Retrieved April 8, 2023, from https://www.cancer.gov/about-cancer/a...

Ju, H.-Q., Lin, J.-F., Tian, T., Xie, D., & Xu, R.-H. (2020). NADPH homeostasis in cancer: Functions, mechanisms and therapeutic implications. Signal Transduction and Targeted Therapy, 5(1). https://doi.org/10.1038/s41392-020-00...

Liberti, M. V., & Locasale, J. W. (2016). The Warburg effect: How does it benefit cancer cells? Trends in Biochemical Sciences, 41(3), 211–218. https://doi.org/10.1016/j.tibs.2015.1...
Roser, M., & Ritchie, H. (2015, July 3). Cancer. Our World in Data. Retrieved April 8, 2023, from https://ourworldindata.org/cancer

Semenza, G. L. (2010). HIF-1: Upstream and downstream of cancer metabolism. Current Opinion in Genetics & Development, 20(1), 51–56. https://doi.org/10.1016/j.gde.2009.10...

What is cancer? National Cancer Institute. (2021). Retrieved April 8, 2023, from https://www.cancer.gov/about-cancer/u...


00:00 - A short summary of cancer
00:38 - ATP
01:46 - Anaerobic respiration
02:24 - Aerobic glycolysis (The Warburg Effect)
05:30 - HIF-1 in glycolysis
06:42 - HIF-1 in cancer cells
07:28 - Inhibitory factor 1
08:21 - Summary


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