Скачать или смотреть Relocalizing Transcriptional Kinases to Activate Apoptosis with Roman Sarott and Sai Gourisankar

In this Research Spotlight episode, Dr. Roman Sarott and Dr. Sai Gourisankar share their work on relocalizing transcriptional kinases to activate apoptosis.

Key reference:
Science 386, eadl5361 (2024)
https://www.science.org/doi/10.1126/s...

Additional references (in order of appearance):
Hanahan and Weinberg, Cell 2011
Bishop et al., Trends Pharmac. Sci. 2017
Hatzi et al., Nat Immunol. 2019; Ptashne and Gann, Nature 1997
Phan & Dalla-Favera Nature 2004; Kerres et al. Cell Rep. 2017
Alerasool et al., Mol. Cell 2022; Kolata, G. The New York Times July 31, 2023
For a review on CDK9 inhibitors: Gu et al. J. Med. Chem. 2022; for BCL6 inhibitors: Wu et al. J. Med. Chem. 2020
Hornberger and Araujo, J. Med. Chem. 2023
Alerasool et al., Mol. Cell 2022; Nabet et al., Nat. Chem. Biol. 2018
For the CDK12/13 inhibitor used in CDK-TCIP3, see Yang et al. J. Med. Chem. 2022
Stanton, Chory, and Crabtree Science 2018; Winter, ACS Chem. Biol. 2024