NAD+ metabolism in aging & 3 strategies to rejuvenate

Video sponsor; Longevity.Technology - https://www.longevity.technology/?utm...

NAD+ is one of the most important molecules in our bodies, however, levels have been shown to decline with age. Understanding NAD+ metabolism (how it is generated and consumed) can be quite complicated and it's still being investigated, yet this understanding will help identify ways to rejuvenate levels of NAD+. One of the best ways to navigate the metabolism is to appreciate the structure and nomenclature of NAD+ and its precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). As you will learn in this video, by understanding the different pathways through which NAD+ is made and used up, there are 3 strategies through which NAD+ levels could be rejuvenated.

You can think of the strategies as make, break or take. How you can enhance production (by activating NAMPT), how you can inhibit breaking down (e.g CD38 inhibitors such as apigenin) and how you can take (NAD+ precursors such as NMN, NR, niacin (NR) and NAM). Majority of work has been conducted in preclinical models however as I'll explain clinical trials are also in progress.

Timestamps;
Intro - 00:00
Why NAD+ metabolism is important - 00:45
NAD+ decline and hallmarks of aging - 05:20
3 strategies to rejuvenate NAD+ - 08:15
Dietary supplementation - 09:00
NAD+ consumption - 13:00
NAD+ biosynthesis - 13:55
Further questions - 14:30
Sponsor & outro - 15:30

References;
Covarrubias, A.J., Perrone, R., Grozio, A. et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 22, 119–141 (2021). https://doi.org/10.1038/s41580-020-00...
Nicotinamide mononucleotide (NMN) deamidation by the gut microbiome and evidence for indirect upregulation of the NAD+ metabolome
doi: https://doi.org/10.1101/2020.09.10.28...
Quantitative analysis... https://doi.org/10.1016/j.cmet.2018.0...
NR discovery - https://doi.org/10.1016/S0092-8674(04...
Trammell, S., Schmidt, M., Weidemann, B. et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun 7, 12948 (2016). https://doi.org/10.1038/ncomms12948

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