Скачать или смотреть AI FINDS HEART DISEASE CURE? - I made LLMs analyze medical studies [reasoning test]

#ai #health #science
https://x.com/HowToUseAI_/status/1895...
Testing the assumption that language models are not ready to produce new analysis or findings on problems, I provided 5 - 12 medical studies on heart disease to the following language models:
-3.7 Sonnet
-Gemini 2.0 Pro Experimental 02-05
-DeepSeek R1
-ChatGPT o1

I used this prompt:

Given all of these studies on heart disease, gather and analyze the findings, assumptions, techniques, facts, data and methods of all studies. Compare all of those outputs to all of your baseline knowledge about heart disease. Produce in two sentences the most significant possible realization or finding about heart disease that could lead to better treatment, an overall cure methodology, or a preventative strategy that could reduce deaths from heart disease significantly. Do not provide additional details other than those two sentences, you can blend your justification and reasoning into those sentences but keep the output at an "elevator pitch level".

Responses in this thread, tag a doctor to judge if any of these are novel/interesting/bland/wrong

Gemini 2.0 Pro Experimental 02-05:
Targeting inflammation and the neurohormonal mechanisms, not just standard lipid lowering, provide the greatest mortality reductions in patients with both high and low cardiovascular risks; future personalized, preventative care could include low-dose polypills containing both an anti-inflammatory combined with a low-dose statin, and two or more anti-hypertensives to reduce morbidity before a first major adverse cardiovascular event, while mitigating potential side effects.

3.7 Sonnet:
Long-term statin therapy significantly reduces cardiovascular mortality and morbidity across diverse patient populations, with greater LDL cholesterol reduction correlating with better outcomes, suggesting aggressive lipid-lowering therapy should be a cornerstone of treatment. Beyond lipid lowering, statins appear to improve endothelial function through pleiotropic effects, which may explain their substantial clinical benefits even in patients with only modestly elevated cholesterol levels.

DeepSeek R1:
The integration of lipid-lowering statins with anti-inflammatory therapies and neurohormonal modulators (e.g., ARNIs) addresses cholesterol, inflammation, and vascular stress pathways, reducing cardiovascular mortality by up to 35%, while early intervention in high-risk populations—even with borderline biomarkers—through personalized, multi-targeted regimens could prevent over 50% of avoidable heart disease deaths globally.

o1:
Aggressive, sustained reduction of LDL cholesterol combined with systematic control of other key risk factors (like hypertension and inflammation) can markedly decrease both the progression of coronary atherosclerosis and the incidence of fatal cardiac events. Taken together, these studies imply that a broad yet targeted approach — involving statins, blood-pressure management, and potentially anti-inflammatory strategies — offers the most powerful prevention and treatment pathway to dramatically lower heart disease mortality.