Szállási Zoltán — Új rák terápiás módszerek: gyógyítható lesz-e a daganatos betegség?

Előadó: Dr. Zoltán Szallasi, Assistant Professor, Pediatrics, Harvard Medical School and Boston Children's Hospital

Cím: Új rák terápiás módszerek: gyógyítható lesz-e a daganatos betegség (és ha igen mikor?)

Abstrakt: Az utóbbi évtizedben több forradalmian új rák terápiás módszer is megjelent a klinikai gyakorlatban, mint pl. az immunellenőrzőpont-gátlókon alapuló, illetve a DNS-javító mechanizmusok hiányát szintetikus letalitáson keresztül kihasználó terápiás stratégiák. Az előadás ezeket az új megközelítéseket fogja áttekinteni első sorban saját eredményeink alapján.

Bio: Dr. Szallasi received his Doctor of Medicine degree from the University of Medicine in Debrecen, Hungary, in 1988. He did postdoctoral research in molecular pharmacology of cancer at the National Cancer Institute. As a faculty member, first at the Uniformed Services University of Health Sciences and currently at Boston Children's Hospital and Harvard Medical School, he has become active in the high throughput analysis of breast cancer. He has published over 100 peer-reviewed articles, mainly on the molecular pharmacology and high throughput analysis of cancer.

Dr. Szallasi's group is interested in the application of high throughput measurements for cancer research. They implemented several methods that increased the reliability of microarray and next generation sequencing measurements. They are also interested in approaches that combine genomic scale measurements in a manner that describe essential cancer biology in a robust fashion. Dr. Szallasi is currently developing methods that determine and quantify specific DNA repair pathway aberrations in human tumor biopsies. This work led to a DNA aberration profile-based method that predicts response to platinum-based therapy with high accuracy, and which is currently in the final stages of comprehensive clinical validation.