Conférence - E. VIVIER - Manipulation des cellules Natural Killer vers des thérapies personnalisées

Conférence de Eric VIVIER intitulée Manipulation des cellules Natural Killer: vers des thérapies personnalisées

00:00:00 Manipulation des cellules Natural Killer: vers des thérapies personnalisées
00:01:16 NK Tumor cell
00:01:59 Effector and regulatory functions of NK cells
00:03:24 NK cell recognition strategies
00:03:49 Recognition of self
00:04:32 Recognition of dysregulated self
00:05:58 NK cellsrecognizedysregulated self
00:06:24 KIR-MHC class I interactions
00:07:02 Recognition of dysregulated self:
00:10:08 LIRILUMAB (IPH 2102): a fully human mAb blocking KIR /HLA interaction
00:10:41 LIRILUMAB
00:11:20 Testing the efficacy of anti-KIR mAb in a pre-clinical model
00:12:08 HLA-C-expressing tumor escapes NK cell control in KIR transgenic mice
00:12:55 anti-KIR treatment improves mouse survival in a HLA+ tumor model

00:13:41 NK cell mAb-therapy: LIRILUMAB (550+ patients)
00:14:25 Phase 1 clinical trial: IPC and CIML Didier Blaise, Christian Chabannon
00:15:15 Checkpoints in immunity
00:16:38 The new paradigm: inhibiting the inhibition
00:17:56 Recognition of dysregulated self: clinical applications
00:18:15 The new paradigm: inhibiting the inhibition
00:18:30 Checkpoints in immunity
00:18:35 The new paradigm: inhibiting the inhibition
00:19:47 The missing link between academic research and industry
00:20:01 Marseille Immunopole


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