Are Reflux Medications DANGEROUS for infants? (What are the RISKS of PPI use in INFANTS!)

Описание к видео Are Reflux Medications DANGEROUS for infants? (What are the RISKS of PPI use in INFANTS!)

SO you have a child that vomits a lot, and you have recently been given some medications (PPI's in this case) to help with this.

Are there risks with taking these medications? Is there a benefit?

Have a watch to find out!

REFS:
1. Tighe M, Afzal NA, Bevan A, Hayen A, Munro A, Beattie RM. Pharmacological treatment of children with gastro-oesophageal reflux. Cochrane Database Syst Rev. 2014;2014(11). doi:10.1002/14651858.CD008550.pub2
2. Davidson G, Wenzl TG, Thomson M, et al. Efficacy and safety of once-daily esomeprazole for the treatment of gastroesophageal reflux disease in neonatal patients. J Pediatr. 2013;163(3). doi:10.1016/j.jpeds.2013.05.007
3. Van Der Pol RJ, Smits MJ, Van Wijk MP, Omari TI, Tabbers MM, Benning MA. Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease: A systematic review. Pediatrics. 2011;127(5):925-935. doi:10.1542/peds.2010-2719
4. Brusselaers N, Engstrand L, Lagergren J. Maintenance proton pump inhibition therapy and risk of oesophageal cancer. Cancer Epidemiol. 2018;53:172-177. doi:10.1016/j.canep.2018.02.004
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9. RACGP - Feed thickener for infant reflux. https://www.racgp.org.au/clinical-res.... Accessed February 6, 2021.
10. RACGP - Gastro-oesophageal reflux in children – what’s the worry? https://www.racgp.org.au/afp/2012/may.... Accessed February 6, 2021.
11. Smith CH, Israel DM, Schreiber R, Goldman RD. Proton pump inhibitors for irritable infants. Can Fam Physician. 2013;59(2):156. www.pretx.org. Accessed February 6, 2021.
12. Rosen R, Vandenplas Y, Singendonk M, et al. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. JPGN. 2018;66:516-554. doi:10.1097/MPG.0000000000001889
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14. Orenstein SR, Hassall E, Furmaga-Jablonska W, Atkinson S, Raanan M. Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Assessing the Efficacy and Safety of Proton Pump Inhibitor Lansoprazole in Infants with Symptoms of Gastroesophageal Reflux Disease. J Pediatr. 2009;154(4). doi:10.1016/j.jpeds.2008.09.054
15. Wang Y-H, Wintzell V, Ludvigsson JF, Svanström H, Pasternak B. Association Between Proton Pump Inhibitor Use and Risk of Asthma in Children. JAMA Pediatr. February 2021. doi:10.1001/jamapediatrics.2020.5710
16. Mitre E, Susi A, Kropp LE, Schwartz DJ, Gorman GH, Nylund CM. Association between use of acid-suppressive medications and antibiotics during infancy and allergic diseases in early childhood. JAMA Pediatr. 2018;172(6). doi:10.1001/jamapediatrics.2018.0315

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