Скачать или смотреть Transient Cr2+ dimers for selective glucose conversion

Chromium chloride in ionic liquids is an efficient chemocatalytic system for the conversion of glucose to 5-hydroxymethylfurfural. The reaction represents one of the key reaction steps in the overall conversion of cellulose to liquid hydrocarbon fuels and useful chemicals. The mechanism of the reaction was studied by a combination of spectroscopic and theoretical methods. A remarkable finding of this study was the unexpected relationship of chemocatalytic glucose activation by Cr2+ and known biocatalytic routes to activate glucose. Whereas coordination of the substrate to the Cr2+ complex is not controlled as well as in enzymes, there is a remarkable similarity. Interaction of the glucose substrate with the Cr2+ cations results in a reactive system only when a second Cr2+ center becomes directly involved. Enzymes usually adapt their topology as a function of reaction progress.

For more information, see:
E.A. Pidko, V. Degirmenci, E.J.M. Hensen “On the Mechanism of Lewis Acid Catalyzed Glucose Transformations in Ionic Liquids”, ChemCatChem 2012, 4, 1263 (http://dx.doi.org/10.1002/cctc.201200....
E.A. Pidko, V. Degirmenci, R.A. van Santen, E.J.M. Hensen “Coordination properties of CrII and CuII chlorides and their complexes with glucose in dialkylimidazolium-based ionic liquids”, Inorg. Chem. 2010, 49, 10081 (http://dx.doi.org/10.1021/ic101402r).
E.A. Pidko, V. Degirmenci, R.A. van Santen, E.J.M. Hensen “Glucose dehydration by transient Cr2+ dimers”, Angew. Chem. Int. Ed. 2010, 49, 2530 (http://dx.doi.org/10.1002/anie.201000....

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Animation: ICMS Animation Studio
Voice-over: Studio Make
Music: "Nebulas Night" by Jason Livesay