What happens when you take antidepressants (and why antidepressants take so long to work)

The video why antidepressants take so long to work by explaining cognitively what happens when you take antidepressants.
💡Anti-depressant Course: https://www.psycho.farm/antidepressan...

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1 Page Summary of Paper: https://drive.google.com/file/d/1PToW...
Paper: https://pubmed.ncbi.nlm.nih.gov/19648...

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The video delves into what happens when you take antidepressants and explores why antidepressants take so long to work. It discusses that while the reuptake of monoamines like serotonin and norepinephrine occurs immediately after taking antidepressants, their clinical effects take weeks to manifest. Traditional neurobiological theories attribute this delay to changes in receptors or gene expression. However, the video presents a cognitive neuropsychological hypothesis suggesting that antidepressants work by correcting negative affective biases, leading to gradual improvements in mood and behavior. It emphasizes that antidepressants don't directly enhance mood but rather change how individuals process emotional information, allowing for more positive interpretations. This shift in emotional processing affects social behavior, reinforcing positive associations and reducing withdrawal. The video illustrates how antidepressants decrease recognition of negative stimuli and increase attention to positive cues, ultimately influencing mood over time. This cognitive approach aligns with cognitive behavioral therapy principles, suggesting that antidepressants modify early stages of emotional processing, which, in turn, impact conscious evaluation and behavior. Overall, the video highlights the importance of understanding the psychological effects of antidepressants alongside their neurobiological mechanisms in explaining their therapeutic delay.

#antidepressants #ssri #pmhnp