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How does NSAIDS cause Peptic Ulcers

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) can cause peptic ulcers,

How NSAIDs Contribute to Peptic Ulcers
1. *Inhibition of prostaglandins*: NSAIDs block the production of prostaglandins, which are hormone-like substances that help protect the stomach lining.
2. *Reduced mucus production*: With decreased prostaglandins, the stomach lining produces less mucus, making it more susceptible to acid damage.
3. *Increased acid production*: NSAIDs can also increase the production of stomach acid, further irritating the stomach lining.

Risk Factors
1. *Long-term use*: Taking NSAIDs for extended periods increases the risk of peptic ulcers.
2. *High doses*: Taking high doses of NSAIDs increases the risk.
3. *Age*: Older adults are more susceptible to NSAID-induced peptic ulcers.

Prevention and Treatment
1. *Use alternative pain relievers*: Consider alternatives like acetaminophen or COX-2 inhibitors.
2. *Take NSAIDs with food*: Food can help buffer the stomach.
3. *Proton pump inhibitors (PPIs)*: Medications like PPIs can help reduce stomach acid.


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