Скачать или смотреть Methemoglobinemia EXPLAINED: Pathophysiology, Diagnosis & Treatment | USMLE High-Yield Guide

Methemoglobinemia is a condition in which iron in hemoglobin is oxidized from Fe²⁺ to Fe³⁺, resulting in impaired oxygen delivery and tissue hypoxia. In this high-yield USMLE review, we cover the underlying mechanisms, key diagnostic clues, and life-saving treatments that every medical student needs to know.
What You’ll Learn in This Video
✔️ Pathophysiology:
How methemoglobin forms and alters the oxyhemoglobin dissociation curve.
The role of NADH methemoglobin reductase cytochrome-b₅ reductase and minor pathways in keeping methemoglobin 1%.
✔️ Clinical Presentation & Diagnosis:
Classic signs: cyanosis that fails to correct with O₂, chocolate-brown blood, and low pulse-ox readings around 85%.
Differential: distinguishing from sulfhemoglobinemia, heart failure, and congenital haemoglobin M disease
✔️ Treatment:
Methylene blue mechanism: provides an exogenous electron acceptor to NADPH methemoglobin reductase.
Adjuncts: high-flow oxygen, vitamin C for mild cases, and exchange transfusion or hyperbaric O₂ in severe, refractory cases.

Timestamps for Easy Navigation
0:00 Introduction & Overview
0:24 Normal physiology of Hb
7:15 Pathogenesis of methemoglobinemia: Methylene Blue & vit C
13:27 Treatment of Methemoglobinemia
14:34 Why do we use nitrates to treat cyanide poisoning

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⚠️ Disclaimer
This video is for educational purposes only and does not replace professional medical advice. Always consult a healthcare provider for patient care decisions.

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