Invadopodia and Traction Force Assays in Cancer Cells by PAG | Protocol Preview

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Polyacrylamide Gels for Invadopodia and Traction Force Assays on Cancer Cells - a 2 minute Preview of the Experimental Protocol

Rachel J. Jerrell, Aron Parekh
Vanderbilt University Medical Center, Department of Otolaryngology;

Mechanical rigidity in the tumor microenvironment plays a crucial role in driving malignant behavior by increasing invadopodia activity and actomyosin contractility. Using polyacrylamide gels (PAAs), invadopodia and traction force assays can be utilized to study the invasive and contractile properties of cancer cells in response to matrix rigidity.

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