Mechanisms of the effects of prenatal stress on neurodevelopment genetics and epig

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Dr. Beversdorf is currently involved in research on autism, dementia, cognitive effects of stress, the cognitive neuroscience of problem solving ability, functional neuroimaging, and pharmacological modulation of cognition. His work has been published in journals such as Neurology, Journal of Neurology Neuroscience and Psychiatry, Proceedings of the National Academy of Sciences of the United State of America and Lancet. He is also actively involved in the Brain Imaging Center at the University of Missouri. His research has been funded by National Institute of Neurological Diseases and Stroke, National Institute On Drug Abuse, Department of Defense, the Stallone Fund and the National Alliance for Autism Research. He has joined the University of Missouri in the departments of Radiology, Neurology, Psychology and the Thompson Center as an Associate Professor to focus on the field of autism, with particular interest in pharmaco-functional neuroimaging as a potential treatment marker, and gene/stress interactions in the development of autism.

00:00 - Intro
2:00 – Overview of autism and epigenetics
4:30 – Previous data on prenatal stress
6:30 – Serotonin transporter (SERT)
8:00 – Study: Effect of prenatal stress and SERT on sociability
10:15 – Studies: Clinical support for rodent models
13:20 – Other contributing factors
15:00 – Study: Effect of DHA diet and stress
17:30 – Study: DHA before gestation
20:10 – DHA and anti-inflammatory and anti-oxidative pathways
22:10 – Study: Epigenetics mechanisms
27:10 – Study: Clinical epigenetics mechanisms
30:25 – Future directions
31:50 – Thanks and acknowledgements
34:15 – Q&A