Osteoid Osteoma vs Osteoblastoma

Osteoid osteoma and osteoblastoma are both benign tumors of osteoblasts, which are the osteoid-producing, bone-forming cells in the body. Since these tumors both contain osteoid, they each present on x-ray as a bony mass with a radiolucent core.

Osteoid osteoma is smaller than osteoblastoma, and you can think of it as osteoblastoma’s little brother. But this little brother lives in the long bones, because that’s where osteoid osteoma often occurs. It typically has pain that is worse at night; and that pain also improves with NSAID use.

Osteoblastoma on the other hand, is the larger of the two tumor types, and they typically occur in the vertebrae. The pain is not worse at night when compared to day, nor is the pain usually responsive to NSAIDs. Since the pain does not improve with medication, osteoblastomas are treated surgically in order to alleviate the pain.

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