Скачать или смотреть Introducing LocIn: RoukenBio's new targeted integration system for the efficient creation of...

Presented By: Dr Timothy London

Speaker Biography: Dr Timothy London is the Director of Molecular Biology & Cell Engineering at RoukenBio, where he leads the development of cutting-edge cell line engineering platforms and novel solutions. With a PhD in Molecular Biology from the University of Cambridge, Tim has over a decade of experience in biopharmaceutical research, including MedImmune where he was involved in antibody discovery and optimization campaigns, and TC BioPharm, where he played a pivotal role in developing early-stage CAR-T programs. At RoukenBio, he has spearheaded innovations in inducible expression systems and expanded the company’s services to include custom cell line engineering. Tim is a co-inventor on multiple patents in CAR-T therapies and cell line development. Passionate about advancing therapeutics that improve patient outcomes, he thrives on tackling the unique challenges presented by diverse client projects. Join Tim at IO360 to learn how RoukenBio’s cutting-edge solutions like IndEx-2 can accelerate your therapeutic development.

Webinar: Introducing LocIn: RoukenBio's new targeted integration system for the efficient creation of isogenic mammalian cell lines

Webinar Abstract: LocIn is an advanced targeted integration system designed for the efficient generation of cell lines by retargeting pre-defined genomic loci, known as "landing pads." These landing pads incorporate a fluorescent protein marker, enabling the easy identification of integrations at genomic sites that support high transgene expression. The system leverages Recombinase Mediated Cassette Exchange (RMCE) to precisely replace the landing pad cassette with a gene of interest. This approach ensures the complete removal of the original cassette during retargeting while exclusively integrating the desired gene. By eliminating positional and context-dependent effects, LocIn enables accurate studies of phenotypic outcomes, delivering reliable genotype-to-phenotype correlations.

Labroots on Social:
Facebook:   / labrootsinc  
Twitter:   / labroots  
LinkedIn:   / labroots  
Instagram:   / labrootsinc  
Pinterest:   / labroots  
SnapChat: labroots_inc