Скачать или смотреть Levels of Evidence Explained

This video explains different levels of evidence in medical research. Individual case reports and case control studies can be misleading and give people false confidence in a treatment. I give some examples in multiple sclerosis research where a weaker form of evidence is later overturned by a randomized controlled trial.

Selected Sources

Benefit Trial: https://touchneurology.com/multiple-s...
Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia: https://www.frontiersin.org/journals/...
Intravenous immunoglobulin in relapsing-remitting multiple sclerosis: https://pubmed.ncbi.nlm.nih.gov/18645....
Intravenous Immunoglobulin Treatment Following the First Demyelinating Event Suggestive of Multiple SclerosisA Randomized, Double-Blind, Placebo-Controlled Trial: https://jamanetwork.com/journals/jama...
A randomized crossover study of bee sting therapy for multiple sclerosis: https://pubmed.ncbi.nlm.nih.gov/16221...
The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative: https://www.nature.com/articles/nrneu...
Efficacy and Safety of Extracranial Vein Angioplasty in Multiple SclerosisA Randomized Clinical Trial: https://jamanetwork.com/journals/jama...
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis: https://pubmed.ncbi.nlm.nih.gov/17179...
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial: https://pubmed.ncbi.nlm.nih.gov/24655...


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.