RNA Splicing by the Spliceosome: Supplemental Video 1 - An overview of pre-mRNA splicing

A supplemental video from the 2020 review by Max E. Wilkinson, Clément Charenton, and Kiyoshi Nagai, "RNA Splicing by the Spliceosome," from the Annual Review of Biochemistry: https://www.annualreviews.org/doi/10....

Shown: An overview of pre-mRNA splicing, showing all the conformational changes that occur when going from an mRNA precursor to a fully spliced mRNA. Structures derive from PDB codes 6G90 for yeast A complex, 5GAN for yeast tri-snRNP, 5ZWM for yeast pre-B complex, 5NRL for yeast B complex, 5GM6 for yeast Bact complex, 5LJ5 for yeast C complex, 5MQ0 for yeast C* complex, and 6EXN for yeast P complex. The structure of the full intron RNA is built freely to connect ordered parts of the structures, and is for illustrative purposes only.

Read more about Kiyoshi Nagai's life and spliceosome research here:
https://www2.mrc-lmb.cam.ac.uk/kiyosh...

You can find more videos about RNA splicing and the spliceosome here:
   • RNA Splicing by the Spliceosome  

Another playlist you might be interested in:
Research Highlights in our Structural Studies Division -    • Structural Studies Division  

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