BINA Scientific Speaker Series | Oct 8 2024 - Esteban Miglietta (Spanish Audio)

BINA Scientific Speaker Series | Esteban Miglietta, October 8, 2024

For more details on this series & to register to join us, please visit:
https://www.bioimagingnorthamerica.or...

This session was presented in Spanish and interpreted into English, watch the English Audio version here:    • BINA Scientific Speaker Series | Oct ...  

Presentation Title: Power at the Nanoscale: Judging cells by their looks: building a career path supporting research with quantitative bioimage analysis
Presenter: Esteban Miglietta

Abstract:
In this talk, I will share my career path, first from wet lab neurobiology to microscopy core facility work, with an unexpected detour studying antibody response in COVID-19 vaccines in Argentina, and finally to training as a bioimage analyst in a unique postdoctoral training program.
I will also showcase the work of the Cimini lab in maintaining, developing and promoting the use of CellProfiler and other open tools and datasets, as well as the undergoing translation efforts to facilitate access to training materials for non-English speaking populations, especially in Latin America.
Finally, I will discuss a recent collaboration using high-throughput imaging to characterize the localization pattern of 3,448 missense variants of 1,269 proteins involved in diverse Mendelian disorders and tumorigenesis. This approach allowed us to propose protein mislocalization as a widespread consequence of genetic variation that can help explain pleiotropy, disease severity and provide insights on variants of uncertain unknown significance.