The Molecular Physiology Of Hybrid Training - Professor Keith Baar

Hello and welcome to The Progress Theory where we discuss how to implement scientific principles to optimise human performance. In this episode we have Dr Keith Baar @MuscleScience, Professor of Molecular exercise physiology at the University of California.

One of the mechanisms for the interference effect when hybrid training is molecular signalling theory. When activated by endurance exercise the AMPK pathway may inhibit the mTOR pathway, inhibiting strength and hypertrophy adaptations. But what does this all mean? In this episode, Professor Baar and Dr Phil Price discuss how these molecular pathways get activated, why endurance training might inhibit strength training adaptations, and how we can change our programming to reduce this.

In this episode, we discuss:
1:14 - Introduction
6:03 - What is mTORC1 and AMPK?
10:43 - Factors which activate mTORC1 and AMPK
14:55 - The importance of leucine
18:35 - How long mTORC1 and AMPK stay activated poster exercise
21:53 - Molecular breaks
25:08 - Difference between rats and human studies on concurrent training
31:23 - Untrained vs trained
36:48 - Practical recommendations for hybrid athletes

The host - Dr Phil Price
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In this episode, we mentioned the following resources:
Professor Keith Baar Research
Other researchers
Professor William Apro
Professor Eva Blomstrand
Professor Dave Bishop
Professor Hickson’s first study