Скачать или смотреть Investigating a novel target for gastric cancer therapy, Alice Robinson

Gastric cancer is the fifth most common cancer in Aotearoa. Māori and Pasifika experience younger diagnoses and worse outcomes compared to NZ Europeans. We identified a protein complex controlling immune responses in gastric cancer together with the immunoproteasome. This breaks down intracellular proteins, prolonging inflammation in several cancers through effects on immune cells within the tumour. It is unclear why this complex improves survival in some cancers but worsens outcomes in others. In this project, we examined the role of the immunoproteasome in gastric cancer’s immune response, and whether it is a suitable cancer therapy target. We did not detect statistically significant differences in immune responses toward gastric cancer cells with decreased immunoproteasome subunit expression. However, we found a trend of decreased immune cell migration towards cancer cells in intestinal type gastric cancer with decreased expression of immunoproteasome subunits, but conversely, increases in immune cell migration in the diffuse type.