Скачать или смотреть Alzheimer's, Neuroimaging, Amyloid & Tau - The Fredericks Lab at Yale School of Medicine

For more information on Carolyn Fredericks or #YaleSchoolOfMedicine, visit: https://medicine.yale.edu/profile/car... and https://www.frederickslab.com.

Most of us think of Alzheimer’s disease as primarily a disease of memory. Many of us have a friend or loved one who has personally experienced this most common “amnestic” form of Alzheimer’s disease, struggling more and more with short-term memory, having trouble finding their way on familiar roads, and asking family members repeated questions. And indeed, most of the time Alzheimer’s disease targets brain structures that specialize in supporting these functions. However, for reasons we don’t yet understand, Alzheimer’s sometimes targets brain structures and networks that are specialized for visuospatial processing (in which case we call it posterior cortical atrophy), or for certain aspects of language (logopenic aphasia), or for organization and judgment (frontal variant Alzheimer’s disease). The Fredericks Lab focuses on these less common forms of Alzheimer’s disease, using advanced neuroimaging techniques to better understand how pathology spreads across brain networks. We also have a special interest in understanding the role that small structures within the brain, such as brainstem and thalamic nuclei, play in functional network abnormalities in Alzheimer’s disease. Our hope is that our work will result in earlier identification of illness, precise monitoring of illness for future drug studies, and identification of targets for direct treatments (such as electrical stimulation) in the future, particularly for patients with atypical variants of Alzheimer’s disease. Dr. Carolyn Fredericks’ research laboratory is part of Yale’s Clinical Neuroscience Imaging Center (CNIC), a multidisciplinary group applying innovative imaging methods to the study of brain disease. Clinically, Dr. Fredericks sees patients with a variety of cognitive and behavioral concerns. She specializes in the diagnosis and treatment of neurodegenerative disorders.

0:00 The Fredericks Lab
0:34 What are they studying?
1:17 How are they studying it?
2:27 Where might this research lead?