Sulfa Drugs: the Rise and Fall of Sulfanilamide

Streptococcus bacteria have caused uncountable deaths from infection throughout history, and in 1935, humanity finally got a tool to fight them. Starting in 1932, Bayer and IG Farben started testing compounds for antibacterial properties. This culminated with Prontosil (sulfanilamide) in 1935, one of the first effective antibacterial drugs. It was uniquely poised to take advantage of streptococcus microbiology, whether that was strep pyogenes or pneumoniae.

☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️

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https://www.sciencehistory.org/educat...
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https://www.britannica.com/topic/IG-F...
https://www.nytimes.com/1994/09/13/bu... https://jamanetwork.com/journals/jama...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.ncbi.nlm.nih.gov/pmc/arti... https://royalsocietypublishing.org/do...
https://brill.com/downloadpdf/journal...
https://link.springer.com/chapter/10....
https://www.bayer.com/en/history/gerh...
https://www.thelancet.com/journals/la... https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.nytimes.com/1936/12/17/ar...
https://www.ncbi.nlm.nih.gov/pmc/arti...


⌛T I M E S T A M P S ⌛
0:00 intro
0:22 Bayer, IG Farben, Gerhard Domagk
6:17 Sulfanilamide breaks through
10:24 Dupes and Downfall
13:12 After IG Farben