Скачать или смотреть Antidiabetic drugs pharmacology, thiazolidinediones pharmacology, clinical pharmacology diabetes

💊 Thiazolidinediones, also known as glitazones, are a class of oral antidiabetic agents that improve insulin sensitivity in peripheral tissues. They primarily act on adipose tissue, muscle, and the liver to enhance glucose uptake and utilization, making them effective in treating type 2 diabetes mellitus.

▪️ TZDs (e.g., pioglitazone, rosiglitazone) work by activating PPAR-γ in adipose tissue, increasing insulin sensitivity in muscle and fat while reducing hepatic glucose output.
▪️ TZDs increase renal sodium reabsorption, leading to fluid retention (worsening heart failure risk). Weight gain is due to fat redistribution (subcutaneous, not visceral fat).
▪️ TZDs can cause fluid retention leading to or worsening heart failure, and are contraindicated in NYHA Class III or IV heart failure.
▪️ Pioglitazone improves lipid parameters—especially raising HDL and lowering triglycerides—beneficial for cardiovascular health.
▪️ Rosiglitazone was linked to higher risks of myocardial infarction and cardiovascular death, leading to restricted use (now lifted in some countries with caution).
▪️ TZDs act via gene transcription changes and take weeks to exert full effects, unlike rapid-acting agents like sulfonylureas.
▪️ TZDs decrease bone mineral density and increase the risk of fractures, especially in women.
#thiazolidinediones #glitazones #diabetestreatment #pharmacologylectures #clinicalpharmacology

thiazolidinediones, diabetes, antidiabetic medications, antidiabetic drugs, antidiabetic drugs pharmacology, antidiabetic drugs osmosis, antidiabetic drugs ninja nerd, clinical pharmacology lectures diabetes, clinical pharmacology diabetes, diabetic drugs pharmacology, diabetic drugs pharmacology nursing, diabetes drugs pharmacology, clinical pharmacology lectures, clinical pearls diabetes, pharmacology lecture nursing, pharmacology made easy, thiazolidinediones pharmacology, thiazolidinediones clinical pharmacology, thiazolidinediones clinical pearls, clinical pharmacology made ridiculously simple, clinical pharmacology made simple

Chapters:
0:00 - thiazolidinediones (glitazones) pharmacology
0:21 - thiazolidinediones (glitazones) clinical pharmacology
0:28 - thiazolidinediones (glitazones) and fluid retention (edema)
0:51 - thiazolidinediones (glitazones) and weight gain
1:09 - thiazolidinediones (glitazones) and bone fracture risk
1:32 - thiazolidinediones (glitazones) and bladder cancer
1:51 - thiazolidinediones (glitazones) and hepatotoxicity
2:10 - thiazolidinediones (glitazones) clinical summary

🎯 𝗖𝗼𝗻𝗻𝗲𝗰𝘁 𝘄𝗶𝘁𝗵 𝗺𝗲 𝗼𝗻 𝘃𝗮𝗿𝗶𝗼𝘂𝘀 𝘀𝗼𝗰𝗶𝗮𝗹 𝗺𝗲𝗱𝗶𝗮 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺𝘀 𝘁𝗼 𝗲𝘅𝗽𝗹𝗼𝗿𝗲 𝗺𝗼𝗿𝗲 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝗳𝘂𝗹 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗽𝗲𝗮𝗿𝗹𝘀 𝗮𝗯𝗼𝘂𝘁 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝘆 𝗮𝗻𝗱 𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲:
YouTube👉🏼: https://www.youtube.com/channel/pharm...
Instagram👉🏼:   / pharmacybyasim  
Twitter👉🏼:   / pharmed0929  
Facebook: https://www.facebook.com/profile.php?...
Buy me a coffee👉🏼: https://www.buymeacoffee.com/pharmacy...

🎯 𝗬𝗼𝘂 𝗰𝗮𝗻 𝗮𝗹𝘀𝗼 𝗷𝗼𝗶𝗻 𝗺𝘆 𝗪𝗵𝗮𝘁𝘀𝗔𝗽𝗽 𝗮𝗻𝗱 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗴𝗿𝗼𝘂𝗽𝘀 𝗳𝗼𝗿 𝗱𝗮𝗶𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀 𝗮𝗻𝗱 𝘃𝗮𝗹𝘂𝗮𝗯𝗹𝗲 𝗽𝗵𝗮𝗿𝗺𝗮𝗰𝗼𝗹𝗼𝗴𝘆 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀:
WhatsApp: https://chat.whatsapp.com/LYSaMZBsutA...
Telegram: https://t.me/+kjJ4_Cg4CMc5MDY0

☑️ 𝙁𝙤𝙧 𝙖𝙣𝙮 𝙌𝙪𝙚𝙧𝙞𝙚𝙨 𝙖𝙣𝙙 𝙎𝙪𝙜𝙜𝙚𝙨𝙩𝙞𝙤𝙣𝙨 𝙀𝙢𝙖𝙞𝙡 𝙤𝙣: [email protected]

𝗗𝗶𝘀𝗰𝗹𝗮𝗶𝗺𝗲𝗿:
"Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition."