Скачать или смотреть Kidney SLC Transporter Cells – Reliable Tools for Assessing Renal Solute Passage and Drug Toxicity

When developing cell based assays many toxicologists encounter challenges such as obtaining cells with high biological relevance and enough proliferative capacity to support the throughput of the assay without introducing cell variability. Additionally, while kidney membrane transporters are key to drug disposition and renal clearance, many of the current renal models lose the expression of organic anion transporter (OAT) 1 and 3 and organic cation transporter (OCT) 2 in culture. To address these issues, ATCC scientists have created physiologically relevant transporter cell models using hTERT-immortalized primary renal proximal tubule epithelial cells (RPTEC) that stably overexpress the OAT1, OCT2, or OAT3 gene. Join this webinar to see data indicating that these cell lines are provide tissue-relevant results, improved consistency over time, and predictability for clinical trials.