ETHANOL METABOLISM IN THE LIVER. Pathogenesis of Alcoholic hepatitis.

0:01 Alcohol metabolism
0:18 Alcohol detoxification in the Liver tissue
1:10 Alcohol Dehydrogenase and Zero order kinetic
2:26 How alcohol affects brain tissue ( Hangover pathogenesis)
3:33 Mechanism of Lactic acidosis
4:37 Inhibition of Gluconeogenesis (Fasting Hypoglycemia)
5:42 Increase in Glycerol 3 phosphate / decrease in dihydroxyacetone phosphate
6:38 Inhibition of the Krebs cycle
7:30 Mechanism of Increase in ketone bodies production (Ketoacidosis)

Step 1 High Yield Topic.

Pathogenesis of Alcohol-induced Lactic acidosis. Fasting hypoglycemia. Ketoacidosis. Hepatosteatosis. Mechanism of Fomepizole and Disulfiram.

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