Скачать или смотреть COVID-19 and FAVIPIRAVIR/AVIGAN/AVIFAVIR/FABIFLU - A Scientific Perspective

This is the sixteenth video in the series of SARS-CoV-2 pandemic.
Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses. Favipiravir was discovered through screening chemical library for anti-viral activity against the influenza virus by Toyama Chemical Co., Ltd. Favipiravir undergoes an intracellular phosphoribosylation to be an active form, favipiravir-RTP (favipiravir ribofuranosyl-5′-triphosphate), which is recognized as a substrate by RdRp, and inhibits the RNA polymerase activity. Since the catalytic domain of RdRp is conserved among various types of RNA viruses, this mechanism of action underpins a broader spectrum of anti-viral activities of favipiravir. Favipiravir is effective against a wide range of types and subtypes of influenza viruses, including strains resistant to existing anti-influenza drugs. Of note is that favipiravir shows anti-viral activities against other RNA viruses such as arenaviruses, bunyaviruses and filoviruses, all of which are known to cause fatal hemorrhagic fever. These unique anti-viral profiles will make favipiravir a potentially promising drug for specifically untreatable RNA viral infections.
Since the catalytic domain of RdRp is conserved among various types of RNA viruses, this mechanism of action may underpins a broader spectrum of antiviral activities of favipiravir. Favipiravir-RTP inhibits RdRp of the influenza virus with an IC50 of 0.022 µg/mL, but does not affect the human DNA polymerases α, β, γ subunits at up to 100 µg/mL. In addition to the inhibition of influenza virus, favipiravir shows inhibitory effects on a wide range of RNA viruses, such as arena-, bunya-, flavi- and filoviruses causing hemorrhagic fevers. It has been shown to be effective in the treatment of influenza and in some extent Ebola virus disease. Genome sequencing of SARS-CoV-2 identified the virus as a single-stranded RNA beta-coronavirus with the RdRp gene similar to those of SARS-CoV-1 and MERS-CoV. Therefore, favipiravir is considered as one of the potential candidates for COVID-19, though confirmed in vitro and preclinical animal studies are not available yet. In an in-vitro study, SARS-CoV-2 was inhibited by favipiravir in Vero E6 cells with an EC50 of 61.88 µMol. But in another study favipiravir showed no apparent antiviral effect against the SARS-CoV-2 virus in vitro at concentrations under 100 μML.

References -
1. Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
https://www.ncbi.nlm.nih.gov/pmc/arti...

2. Antiviral treatment of COVID-19
https://www.ncbi.nlm.nih.gov/pmc/arti...

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COVID-19 Video Links -
1. Coronavirus (COVID-19) - Virology and Outbreak -    • SARS-CoV-2 - Virology and Outbreak  

2. Coronavirus (COVID-19) - ACE and ARB Dilemma -
   • COVID-19 - ACE and ARB Dilemma  

3. Coronavirus (COVID-19) - Treatment - REMDESIVIR - Hype or Real -
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4. Coronavirus (COVID-19) - Treatment - Chloroquine + Azithromycin - Hype or Real Part II
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5. Coronavirus (COVID 19) -Treatment/Cure - Chloroquine + Azithromycin - Hype or Real
   • Coronavirus (COVID 19) and Chloroquine + A...  

6. Coronavirus (COVID-19) - Treatment/Cure - Tocilizumab - Hype or Real
   • COVID-19 and Tocilizumab - A Scientific Ap...  

7. Coronavirus (COVID-19) - Why Are Men More Affected Than Women? - Pathogenesis and Receptor Binding
   • COVID-19 - Why Are Men More Affected Than ...  

8. Coronavirus (COVID-19) - Treatment/Cure - RNA Dependent RNA Polymerase Analysis
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9. COVID-19 and Diabetes - Treatment/Cure - DPP4 Inhibitors - Hype or Real
   • SARS-CoV-2 and Diabetes - DPP4 Inhibitors ...  

10. COVID-19 and Ivermectin - A Scientific Approach
   • COVID-19 and Ivermectin - A Scientific App...  

11. COVID-19 and ARDS - Vascular Complications
   • SARS-CoV-2 and ARDS - Vascular Complications  
2. IL-6: from its discovery to clinical applications
https://academic.oup.com/intimm/artic...

12. CD 147 - An Alternative Receptor For SARS-CoV-2
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13. SARS-CoV-2 and Interleukin 6 - Complications in COVID-19
   • SARS-CoV-2 and Interleukin 6 - Complicatio...  

14. COVID-19 and LERONLIMAB - A Scientific Perspective
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