Скачать или смотреть How Plasmids Adapt to Antibiotic Pressure: The Case of mcr-1 and Colistin Resistance

Explore the fascinating world of plasmid evolution and its role in antibiotic resistance. This video delves into a groundbreaking study on the mcr-1-harboring IncI2 plasmid, a major driver of colistin resistance. Discover how these plasmids exhibit dual evolutionary strategies: optimizing horizontal transfer in the absence of colistin and prioritizing stability under selective pressure. Learn about the methods used, including laboratory evolution experiments, whole-genome sequencing, and bioinformatic analysis. Understand the implications of these findings for the persistence and dissemination of colistin resistance and the evolutionary trade-offs shaping plasmid-host coadaptation. Perfect for microbiology, genetics, and antibiotic resistance enthusiasts.
Key Topics:
Plasmid-mediated colistin resistance
IncI2 plasmids and mcr-1 gene
Laboratory evolution experiments
Whole-genome sequencing and bioinformatic analysis
Evolutionary strategies of plasmids
Implications for antibiotic resistance
Stay tuned for more insights into the complex world of microbial evolution and antibiotic resistance!