Structural Activity Relationships(SAR) of Benzodiazepines - Lorazepam, clonazepam

Описание к видео Structural Activity Relationships(SAR) of Benzodiazepines - Lorazepam, clonazepam

Every position in the benzodiazepine ring show some relation to their pharmacological activity, so studying SAR of benzodiazepines is a good aspect to understand their relative activity. For example, drugs like Lorazepam, Oxazepam, Temazepam have hydroxyl group at 3rd position which renders the drugs relatively polar in nature thereby directly excreted in the urine without any significant phase I metabolism. That's why these drugs have short duration of action.

0:00 Introduction
0:03 Common structure of benzodiazepines
1:12 1st position
1:59 2nd position
3:43 LOT : Lorazepam, Oxazepam and Temazepam are polar
6:06 8th and 9th positions
7:53 Fused ring systems

#xanaxs
#lorazepam
#clonazepam

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