Accelerating the Antibody Discovery Workflow in the Modern Therapeutic Landscape

Presented By: François Romagné

Speaker Biography:
Professor of immunotechnology at Aix-Marseille University (AMU), François Romagné contributed to the creation of MImAbs, where he has been the Scientific Director ever since. He brings his knowledge and his experience of antibody generation, antibody engeneering and their preclinical characterization, both in diagnostics (14 years spent within the immunodiagnostic company Immunotech) and in therapeutic applications (14 years as Chief Scientific Officer of Innate Pharma, a company that he was co-founder). He supervised the generation of many different antibodies from inception to preclinical profiling and clinical development.
François is the author of over 50 scientific publications and 15 patents.

Webinar: Accelerating the Antibody Discovery Workflow in the Modern Therapeutic Landscape

Webinar Abstract:
Despite demonstrated efficiency in antibody generation, classical immunization strategies and subsequent hybridoma generation often face strong limitations when it comes to speed and poorly immunogenic membrane proteins with short extracellular domains. Indeed, even if a few antibodies can be obtained with repeated campaigns, only limited diversity and molecular characteristics are sometimes achieved, resulting in difficulties in selecting good candidates for pharmaceutical developments. Innovative approaches combining RNA immunization and single cell screening provide unique opportunities to dramatically speed up antibody discovery against such challenging targets. In the presentation, rapide obtention of large collections of antibodies with both molecular and function diversity on ‘classical’ targets as well as against a difficult GPCR and ion channel will be examplified using these strategies.

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