Скачать или смотреть Psychedelic Science: Benefits in Depression; PTSD Addiction (Castano Perez & Castano Ocampo, 2025)

I. The Resurgence Of Psychedelic Science
Scientific interest in psychedelics has returned after decades.
Researchers are exploring treatments for mental disorders.
Studies show efficacy where conventional treatments often fail.
New rigor involves identifying specific brain mechanisms.
Legal barriers have historically hindered this important research.
Recent shifts allow for controlled clinical trials globally.

II. How Psychedelics Affect The Brain
Classic psychedelics activate serotonin 5-HT2A receptors.
This activity promotes structural neural plasticity in the brain.
Substances like LSD can increase dendritic spine density.
They reduce activity in the default mode network (DMN).
The DMN is associated with self-referential thinking and rumination.
Disruption of the DMN helps break rigid negative thought patterns.
This process facilitates cognitive flexibility and introspection.

III. Treating Depression And Anxiety Disorders
Psilocybin shows promise for treatment-resistant depression.
Studies indicate rapid and lasting symptom reduction.
Effect sizes in some trials exceed those of traditional meds.
It is effective for anxiety related to life-threatening illness.
LSD has shown sustained anxiolytic effects in clinical trials.
Rapid effects suggest a unique mechanism compared to SSRIs.

IV. Breakthroughs For PTSD And Trauma
MDMA combined with therapy is effective for severe PTSD.
It enhances feelings of safety, empathy, and social bonding.
This allows patients to process traumatic memories less aversively.
Remission rates in trials were higher than with placebo.
MDMA increases oxytocin release to facilitate trust.
It improves connectivity between emotional and cognitive centers.

V. Applications For Addiction Recovery
Psilocybin helps reduce heavy drinking days in alcohol use disorder.
It helps disrupt rigid patterns involved in compulsive behaviors.
Studies show high success rates for smoking cessation.
Ibogaine is being studied for opioid detoxification and recovery.
These substances may help reverse maladaptive brain changes.
Psychedelics can reduce cravings and improve mental outlook.

VI. Obsessive-Compulsive And Neurodegenerative Disorders
Psilocybin may help break obsessive-compulsive patterns.
It promotes the flexibility needed to overcome cognitive rigidity.
Psychedelics are being tested for Alzheimer’s disease.
Neuroplasticity may help restore deteriorated cognitive functions.
Anti-inflammatory properties might protect neurons.

VII. Safety Protocols And Challenges
Therapy always occurs in a controlled, supervised setting.
Integration with psychotherapy is crucial for safety and efficacy.
Potential risks include transient anxiety and nausea.
Careful screening excludes patients with psychosis history.
Standardized training for therapists is currently a challenge.
Large-scale trials are needed to confirm long-term safety.

VIII. Additional Resource Support
Please visit the NourishED RFi Resource Support Page.
https://notebooklm.google.com/noteboo...

IX. Source
Castaño-Perez, G., & Castaño-Ocampo, S. I. (2025). Therapeutic Potential of Psychedelics: Mechanisms, Applications, and Challenges. In *Psychedelic Drugs – Therapeutic and Recreational Use*. IntechOpen. http://dx.doi.org/10.5772/intechopen....

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