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Globozoospermia, Semen analysis Teratozoospermia Most of the family with genetically abnormal babies Most complex cases of male infertility.

Globozoospermia (100% round-headed sperm, without acrosomal cap) is an uncommon disorder of sperm morphology associated with severe male infertility. Before the ICSI era, patients with this type of disorder were considered sterile. Major morphological defects described so far with this disorder are the absence of an acrosomal cap and an abnormal perinuclear cytoskeleton. Although the main reason for fertilization failure by IVF is the lack of acrosome reaction to penetrate the zona pellucida, it is still rare to achieve pregnancy even after ICSI. It is yet unclear whether some other defects co-exist, which may have a further impact on sperm function and ultimately the fertilization process. Since this entity is universally rare, only single case reports or case series have been reported. Fertilization and pregnancy rates in these reports have always been low, despite the application of ICSI. The first live birth in a couple with globozoospermia was reported in 1994, by ICSI

Mr. Mohammed Nissar is a highly experienced and Chief Embryologist in Hyderabad, Telangana. He carries 23 years of experience in the field of Embryology in India, Saudi Arabia, and Kuwait. 300+ PGDs (Pre Genetic Diagnosis) done. Having extensive experience of male infertility Azoospermia, Cryptozoospermia. Connect with us on:- To consult a specialist Embryologist https://bit.ly/3cOuh23 Visit our website at https://ivfembryologyworld.com/

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