Epstein Barr Virus or Human Herpes virus 4 and Burkitt Lymphoma ; Symptoms and Treatment

The Epstein-Barr Virus (EBV) is closely linked to Burkitt Lymphoma, a type of aggressive B-cell lymphoma. Here are some key points about their connection:

EBV and Burkitt Lymphoma Types: Burkitt Lymphoma has three main forms: endemic (common in Africa), sporadic (found worldwide), and immunodeficiency-associated (often seen in HIV patients). The endemic variant is strongly associated with EBV, with over 95% of cases being EBV-positive.

EBV's Role: EBV infects B-cells and can drive their transformation into cancerous cells. The virus's latency proteins play a crucial role in this process by promoting cell proliferation and inhibiting apoptosis (programmed cell death).

MYC Gene Translocation: A hallmark of Burkitt Lymphoma is the translocation of the MYC gene, which leads to its overexpression and contributes to the cancerous growth of B-cells.

Co-factors: In addition to EBV, other factors like malaria (in the case of endemic Burkitt Lymphoma) and immunodeficiency can contribute to the development of this cancer

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