Lipid Nanoparticle Measurements Advanced with High-Resolution TRPS

Building on our previous discussion of the significance of accurate LNP measurement in nanomedicine, Michele Trott (PhD), Scientific Content Manager at Izon Science, provides a detailed comparison between the widely-used Dynamic Light Scattering (DLS) method and Izon's high-resolution Tunable Resistive Pulse Sensing (TRPS). Through an analysis of mRNA-loaded and empty LNPs, we highlight the precision and advantages TRPS offers to the nanomedicine community. To learn more about Izon’s latest TRPS instrument, the Exoid, visit our website at https://www.izon.com/trps/exoid

Further resources:
Learn about the benefits of TRPS in nanomedicine https://www.izon.com/application/nano...

4 reasons to choose the Exoid: https://www.izon.com/news/4-reasons-w...

Got questions? Reach out for a chat: https://www.izon.com/contact

00:00 - Introduction
01:16 - Limitations of DLS for lipid nanoparticle measurement
02:10 - Intro to Tunable Resistive Pulse Sensing
02:44 - In-house TRPS measurements of empty and mRNA-loaded LNPs
04:00 - Concentration of LNPs measured by TRPS
04:07 - Differences in sensitivity
04:41 - Identifying freeze-thaw induced aggregation
05:31 - TRPS measurement of siRNA-loaded liposomes
06:30 - Capabilities of the Exoid