Drugging an undruggable pocket on KRAS

Описание к видео Drugging an undruggable pocket on KRAS

There are more than 100,000 newly diagnosed KRAS cancer patients per year in the US alone. Almost 60% of these tumors carry the G12D and G12V mutations for which no druggable pocket has been demonstrated. The discovery of the first nanomolar inhibitor for the so-called switch I/II pocket, thought to be undruggable, is described. These inhibitors could lead to medicines for cancers of all forms of KRAS including G12D and G12V. https://www.pnas.org/content/pnas/ear...

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