Easily Learn SGA Antipsychotic Receptors (Learn Anti-Psychotics and Anti-Psychotic Differences)"

Easily learn anti-psychotics through their differences including their mechanisms of action, how they interact with anti-psychotic receptors, and the nuanced anti-psychotic medication differences that influence treatment choices.
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The video provides an intuitive way to easily learn anti-psychotics and memorize the similarities and differences among atypical antipsychotics. It categorizes them into subclasses: the "pines" (olanzapine, quetiapine, clozapine), the "dones" (paliperidone, risperidone, ziprasidone, lurasidone), and the "pips and a rip" (aripiprazole, brexpiprazole, cariprazine).

The video introduces the concept of receptor "fountains," which represent the backbone of receptors that each subclass binds to. This helps explain the similarities in side effects within each subclass. For instance, the pines tend to cause more sedation and weight gain due to their affinity for histamine (H1) and muscarinic (M1) receptors.

By understanding these receptor backbones, one can intuit the side effects of a drug based on its subclass, rather than memorizing individual side effects. The video also highlights subtle differences within subclasses, such as olanzapine lacking the alpha-1 receptor, resulting in less orthostatic hypotension compared to quetiapine and clozapine.

Additionally, the video points out patterns within subclasses, like quetiapine and olanzapine being effective in treatment-resistant depression, clozapine and olanzapine causing the most weight gain, and ziprasidone and lurasidone requiring food for better bioavailability.

Overall, the video presents a novel and intuitive approach to comprehending the receptor profiles and side effects of atypical antipsychotics by organizing them into subclasses with shared anti-psychotic receptors backbones, making it easier to grasp the anti-psychotic medication differences among these drugs.

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#psychopharmacology #psychnp #pmhnp

0:00 And everything is going to the beat
0:11 Intro
0:27 SGAs
1:02 The Pines, The Dones, 2 Pips & A Rip
2:20 Chemistry is just shapes!
2:29 Receptor Profile
3:27 More fountains!
4:53 Charts suck
7:33 Little Patterns
8:35 End Screen