Скачать или смотреть Long lasting disruption to neurocircuitry following adolescent stress, Isabel Ayora

Long lasting disruption to neurocircuitry following adolescent stress: role of epigenetics.
Stress during adolescence has lasting impacts on the functioning of the adult brain. This study used an animal model to investigate how these lasting impacts might reflect changes to the control of a key gene, DAT1, and whether these changes differed between males and females. DAT1 is responsible for the Through measurements of relative DAT1 expression compared between isolated and control rats (kept in pairs), a significantly greater expression of DAT1 was identified in the isolated rats. There was no evidence that this effect differed between male and female rats. These findings are limited by the small number of rats available for analysis, especially female control (paired) rats (of which there was only one). Conclusions about the mechanism for this increased DAT1 expression are still on hold until the converted sequences of the key DAT1 control regions are returned for analysis.