Troponins as Cardiac Biomarker its Importance &Clinical Significance - Cardiac Troponin cTnT, cTnI

#cardiacbiomarker #cardiacTroponin
This video explains about Cardiac Troponins as Biomarker for heart attack and their clinical significance

Cardiovascular disease is the leading cause of death among adults in the most developed countries and many developing countries.

One of the most important biochemical tests for the assessment of cardiovascular disease is the measurement of cardiac markers.

Cardiac troponins, due to their sensitivity and specificity, have been recommended as biomarkers of choice for diagnosis of myocardial necrosis.

Cardiac troponins are regulatory proteins that control the calcium mediated interaction of actin and myosin resulting in contraction and relaxation of striated muscle.

Cardiac Troponin T [CTnT] and Troponin I [CTnI] are highly sensitive and specific markers of myocardial injury.

There are tissue-specific isoforms of Troponins they are TnI, TnT, and TnC.

Both cardiac and skeletal muscle express troponin C; whereas troponin T and I are generally thought to be cardiac-specific.

When cardiac injury occurs (from ischemia or various other causes), cardiomyocytes release cardiac troponin into the blood in proportion to the degree of damage.

Troponin levels increase within 3 to 4 hours after the onset of damage and remain high for up to 4 to 7 days (troponin I) or 10 to 14 days (troponin T).



For Queries: [email protected]
Twitter:Me@BioResource

Related Videos:
---------------------------------------------------------------------------------------------------------------
Plotting Bacterial Growth Curve:    • Plotting Bacterial Growth Curve in Excel  
Colony Forming Units:    • CFU: Colony Forming Unit & cfu/ml cal...  
Serial Dilution Methods:    • Serial Dilution Methods & Calaculations  
Copy Number Calculation for qPCR:    • Copy Number Calculation for qPCR  
How to analyze Primer Sequence or Oligonucleotide sequence designed for PCR / qPCR:    • How to analyze Primer Sequence or Oli...  
How to generate qPCR standard curve in excel and calculate PCR efficiency:    • How to generate qPCR standard curve i...  
Real Time qPCR optimization, Calculating PCR Efficiency:    • Real Time qPCR  optimization, Calcula...  
Taqman Assay Vs SYBR Green Assay:    • Real Time PCR Assays- Taqman Assay Vs...  
Resolving poor PCR efficiency:    • Resolving Poor PCR assay Efficiency i...  
Calculating molecular weight of Unknown protein    • How to calculate molecular weight of ...  
Designing qPCR Primers
   • Primer designing for real time PCR us...  
Oligonucleotide Preparation & Purification    • Oligonucleotide Preparation and Purif...  
How to check Oligo Concentration
   • How to check the Oligo concentration ...