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🎧FREE MSRA PODCAST –Chondrosarcoma: Malignant Cartilage Tumours Made Simple 🦴
In this high-yieldDeep Dive episode, we break down chondrosarcoma,the second most common primary malignant bonetumour in adults. Whether you're studying MSK for the MSRA or refreshingyour oncology knowledge, this is everything you need – simplified andexam-focused.

🧠What You’ll Learn –High-Yield Essentials
✅Definition
• Malignant tumourarising from cartilage-forming cells
• Produces cartilage matrix (key histological clue)
• Second most common primary bone malignancyafter osteosarcoma

📌Common Locations
• Pelvis
• Proximal femur
• Proximal humerus
🧬Mnemonic: HORC – Risk Factors
H – Hereditary (e.g. multiple hereditaryexostoses)
O – Older age (40–60 peak)
R – Radiation history
C – Chromosomal mutations (e.g. IDH1/IDH2)

🔍Pathophysiology
• Geneticalterations → uncontrolled proliferation of cartilage cells
• IDH1 and IDH2 mutations frequently implicated
• Tumour producesits own cartilage matrix, aidingdiagnosis

⚖️DifferentialDiagnoses
• Osteosarcoma
• Enchondroma (benign)
• Metastases to bone
• Othercartilaginous tumours

📈Epidemiology
• Rare overall in the UK
• Affects adults aged 40–60, slight male predominance

🩺Clinical Features – Mnemonic: LPS
L – Localised deep pain (most common)
P – Palpable swelling or tenderness
S – Structural symptoms (e.g. compression,fracture, deformity)
⚠️ May be asymptomatic –found incidentally on imaging

🧪Investigations
• X-ray first
• MRI and CTfor soft tissue/bony extent
• Biopsy – mandatory for diagnosis and grading
• Staging: Bonescan, chest CT (check for lung metastases)

🛠️Management
• Mainstay: Surgical resection with clear margins
• Radiotherapy: For high-grade, unresectable, orincomplete excision
• Chemotherapy: Not typically effective forconventional types

📊Prognosis – Key Determinants
• Tumour grade (most important)
• Completeness of surgical resection
• Presence of metastases
• Risk of local recurrence, especially with incompleteexcision

⚠️Complications
• Lung metastases (most common site)
• Local recurrence
• Long-term functional impairment post-surgery
• Radiation sideeffects
• Ongoing pain, psychological impact, mobility issues

📎More MSRA Resourcesfor Chondrosarcoma
📝 Revision Notes:
https://www.passthemsra.com/topic/chondros... (https://www.passthemsra.com/topic/chondros...)
🧠 Flashcards:
https://www.passthemsra.com/topic/chondros... (https://www.passthemsra.com/topic/chondros...)
📖 Accordion Q&A Notes:
https://www.passthemsra.com/topic/chondros... (https://www.passthemsra.com/topic/chondros...)
🎯 Rapid Quiz:
https://www.passthemsra.com/topic/chondros... (https://www.passthemsra.com/topic/chondros...)
🦴 Quiz:
https://www.passthemsra.com/quizzes/chondr... (https://www.passthemsra.com/quizzes/chondr...)

🌐 Access even more FREE resources:
📚PassTheMSRA.com (https://www.passthemsra.com)
🔓FreeMSRA.com (https://www.freemsra.com)

Hashtags
#MSRA#Chondrosarcoma #MSRARevision #MSRATextbook #BoneTumours #MSKRevision #IDH1#OsteosarcomaDifferential #PassTheMSRA #FreeMSRA #MSRAFlashcards#MSRAAccordions #MSRAQuiz

Episode link: https://play.headliner.app/episode/2724717...