Enantioselective Synthesis of (+)-Lucidumone

An organic chemistry minilecture on the Gram-Scale Enantioselective Synthesis of (+)-Lucidumone by Guanghao Huang, Cyrille Kouklovsky, and Aurélien de la Torre*. It features a highly stereoselective inverse electron demand Diels-Alder reaction, an unusual Mitsunobu reaction of a diketone and a carbon dioxide extrusion- intramolecular cycloaddition reaction.



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References:
J. Am. Chem. Soc. 2022, 144, 17803−17807 (This work)
Org. Lett. 2019, 21, 8523−8527 (Isolation)
Nat. Rev. Drug Discovery 2003, 2, 179−191 (Biological Activity)
Angew. Chem., Int. Ed. 2022, e202208185 (Inverse electron demand Diels-Alder of pyrones)