The Impact of Elevated Hemoglobin F (HbF) on HbA1c Results

Описание к видео The Impact of Elevated Hemoglobin F (HbF) on HbA1c Results

Hemoglobinopathy expert, Marco Flamini, explains the science behind the impact of elevated HbF interference on various HbA1c testing methods, including immunoassay, boronate affinity, and HPLC. Some questions he will address include:

What is HbA1c and how is it calculated?

How does elevated HbF affect HbA1c?

How does HbF influence the glycation rate and determination of HbA1c?

Why is the separation of HbF important in HbA1c determination?

How is HbA1c separated and calculated on immunoassay, boronate affinity, and HPLC methods?

How is %HbA1c calculation affected in the presence of HbF on immunoassay, boronate affinity, and HPLC methods?

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