Скачать или смотреть Nozaki–Hiyama–Kishi Reaction Problem Solved!

The Nozaki–Hiyama–Kishi (NHK) reaction mechanism is a synthetic pathway that facilitates the coupling of an aldehyde with an alkenyl or aryl halide using a nickel/chromium catalyst to generate an allylic or aryl alcohol. The reaction begins with the reduction of Ni(II) to Ni(0), which then undergoes oxidative addition to the carbon-halogen bond of the halide. This process results in the formation of a Ni-organometallic intermediate. Following this, transmetalation occurs with Cr(II), leading to a more stable organochromium(III) species. This Cr(III) nucleophile subsequently adds to the carbonyl group of the aldehyde. After the completion of the reaction and subsequent work-up, the final product is obtained as an allylic or aryl alcohol.


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