Скачать или смотреть Pharmacology of Tolnaftate; Mechanism of action, Pharmacokinetics, Uses, Effects

Tolnaftate is a synthetic thiocarbamate antifungal used to treat superficial fungal infections, including athlete’s foot (tinea pedis), ringworm (tinea corporis), and jock itch (tinea cruris). It is available in topical formulations such as creams, powders, sprays, and solutions.

Mechanism of Action
Tolnaftate works by distorting fungal hyphae and inhibiting mycelial growth, preventing the spread of infection. It specifically targets squalene monooxygenase, an enzyme involved in ergosterol biosynthesis, which is essential for fungal cell membrane integrity.

Pharmacokinetics
Absorption: Minimal systemic absorption when applied topically.

Onset of Action: 24 to 72 hours after application.

Metabolism & Excretion: Primarily remains localized in the skin, with minimal systemic metabolism.

Indications
Tolnaftate is used for:

Treatment of tinea pedis, tinea corporis, and tinea cruris.

Prevention of tinea pedis when applied regularly

#Tolnaftate