Top Bipolar Disorder Treatments: The Old, New & PROVEN Options | Dr. Trisha Suppes |

Internationally renowned bipolar disorder expert Dr. Trisha Suppes unravels the latest science in bipolar disorder treatment by breaking down the proven and cutting-edge treatments available today - exploring traditional solutions such as Lithium and mood stabilizers alongside exciting new options like psilocybin, ketamine, and the Ketogenic diet. Dr. Suppes also navigates the complexities of mania and tackles the perennial question: is lifelong medication necessary to live well with bipolar disorder?

00:00 About Dr. Suppes
Medication Treatments
03:00 Is Lithium the Gold Standard?
05:22 Atypical Antipsychotics
07:22 Dangers of Antidepressants?
09:17 Medications Lose Strength?
Non-medication Treatments
10:47 Psychotherapy
12:54 Ketogenic Diet & Nutrition
13:28 Cannabis
14:20 Ketamine
Brain Stimulation Therapies
15:18 rTMS (Transcranial Magnetic Stimulation)
16:01 VNS (Vagus Nerve Stimulation)
17:07 ECT (Electroconvulsive Therapy)
Bipolar Disorder is Complex
18:52 Insight & Denying Bipolar Disorder
22:45 Bipolar I: Need Meds Forever?
23:44 Bipolar II: Need Meds Forever?
26:22 Hypomania Causes Misdiagnosis
28:16 Mixed States
Psychedelics
29:28 Psilocybin & Magic Mushrooms
32:33 Microdosing & LSD
34:02 MDMA
Closing
35:41 Keeping You "A Little Depressed"
37:55 Why Recovery Is Possible
39:06 Reflecting on Research Impact

Dr. Trisha Suppes, M.D., Ph.D., is a distinguished expert on the biology and treatment of bipolar disorder, and mood disorders generally. Dr. Suppes is the Director of Exploratory Therapeutics and Professor at Stanford University in the School of Medicine. At the VA Palo Alto Health Care System, she is Director of the CSP NODES and is the Founder of the Bipolar and Depression Research Program. Her areas of expertise include long-term treatment strategies for bipolar disorder, identification and treatment of bipolar II disorder, treatment of those with bipolar disorders and co-morbid conditions and use of complementary medicine. She has recently launched a new initiative to explore the use of psychedelics for mood disorders and PTSD in Veterans. Dr. Suppes has been integrally involved in numerous initiatives to improve evidence-based treatment for bipolar disorders. Dr. Suppes participated as a member of the DSM-5 Mood Disorders committee on updating the APA DSM-5 criteria for Mood Disorders and was chair of the APA DSM-5 Bipolar Disorder subcommittee. She was the past President of the International Society of Bipolar Disorders (ISBD).

Treatments Referenced 💊
Lithium, Lamotrigine, Clozapine, Depakote/Valproic Acid, Fluoxetine, Quetiapine, SSRIs, Mood Stabilizers, Antipsychotics, Psychotherapy, Psychoeducation, Interpersonal and Social Rhythm Therapy (IPSRT), Keto Diet, Marijuana, Ketamine, Neurostimulation, Repetitive Transcranial Magnetic Stimulation, Vagus Nerve Stimulation Therapy, Electroconvulsive Therapy, Psilocybin, Psilocin, Microdosing, LSD, MDMA

Research Publications Referenced 📑
[1] Risk of recurrence following discontinuation of lithium treatment in bipolar disorder (Suppes, T): https://doi.org/10.1001/archpsyc.1991...
[2] The ISBD task force report on antidepressant use in bipolar disorders (Pacchiarotti, I): https://doi.org/10.1176%2Fappi.ajp.20...
[3] A randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression (Swartz, H): https://doi.org/10.1111/j.1399-5618.2...
[4] Cohort profile: the Swedish National Quality Register for bipolar disorder (BipoläR) (Pålsson, E): https://doi.org/10.1136/bmjopen-2022-...
[5] Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon (Suppes, T): https://doi.org/10.1001/archpsyc.62.1...
[6] Single-Dose Synthetic Psilocybin With Psychotherapy for Treatment-Resistant Bipolar Type II Major Depressive Episodes: A Nonrandomized Open-Label Trial (Aaronson, S): https://doi.org/10.1001/jamapsychiatr...
[7] Repeated low doses of LSD in healthy adults: A placebo-controlled, dose–response study (de Wit, H): https://doi.org/10.1111%2Fadb.13143

Special thanks: Eileen Grace Fischer and Mary Miller

Host: Dr. Erin Michalak
Producer: Caden Poh

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#talkBD Bipolar Disorder Podcast
talkBD gathers researchers, people with lived experience, healthcare providers, and top bipolar disorder experts from around the world to discuss and answer the most important questions about living with bipolar disorder. Episodes are available on all podcast platforms.
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