RHR: The Lipid Energy Model and Lean Mass Hyper-Responders, with Dr. Nicholas Norwitz

In this episode of Revolution Health Radio, Chris Kresser sits down with Dr. Nicholas Norwitz to delve into the lipid energy model and the phenomenon of lean mass hyper-responders. Dr. Norwitz shares his perspective both as a researcher and as someone who personally experienced dramatic increases in LDL cholesterol levels after adopting a low-carb and ketogenic diet. They explore the recent shifts in our understanding of cholesterol's role in cardiovascular disease, particularly in individuals on low-carb diets who are lean but exhibit high LDL levels. Dr. Norwitz also discusses his groundbreaking research, including a provocative self-experiment involving Oreos, that challenges conventional wisdom about cholesterol management. This episode promises to shed light on the complexities of heart disease risk, dietary impacts on lipid profiles, and the potential implications for future research and clinical practice.

In this episode, we discuss:
--Lean Mass Hyper-Responders and Dr. Norwitz’s Oreo vs Statin Study
--The Lipid Energy Model: A New Perspective
--Challenging Conventional Wisdom: LDL's Role in Cardiovascular Disease
--The Problematic Research Ecosystem for Nutrition and Metabolism
--Other Potential Risk Factors Contributing to Cardiovascular Disease

Show notes:
--Research Paper: “Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin Therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment”
https://www.mdpi.com/2218-1989/14/1/73
--Oreo vs Statin Tweet on Dr. Norowitz’s X
  / 1749426902274580911  
--The Oreo vs Statin study YouTube video
   • Oreos are the Most Potent Drug for LD...  
--Dr. Norwitz on Twitter/X @nicknorwitz
  / nicknorwitz  
--Professor William Cromwell on Twitter/X @lipoprotein
https://twitter.com/lipoprotein?lang=en
--Dave Feldman on Twitter/X @RealDaveFeldman
  / realdavefeldman  
--If you’d like to ask a question for Chris to answer in a future episode, submit it at https://chriskresser.com/podcastquest...



This episode of Revolution Health Radio is sponsored by LMNT.

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Chris Kresser M.S., L.Ac. is the co-founder of the California Center for Functional Medicine, the founder of Kresser Institute, the host of the top-ranked health podcast Revolution Health Radio, the creator of ChrisKresser.com, and the New York Times best-selling author of The Paleo Cure and Unconventional Medicine. He is one of the most respected clinicians and educators in the fields of Functional Medicine and ancestral health and has trained over 2,000 clinicians and health coaches from more than 50 countries in his unique approach. Chris was named one of the 100 most influential people in health and fitness by Greatist.com and has appeared as a featured guest on Dr. Oz, Time, The Atlantic, NPR, Fox & Friends, and other national media outlets. Throughout his career, Chris has been devoted to exploring the deeper questions surrounding health and wellness. His most recent work is focused on helping people to thrive and flourish even in the midst of chronic illness or other challenging circumstances. He recently launched Adapt Naturals, a supplement line designed to add back in what the modern world has squeezed out and help people perform and feel their best.

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