Скачать или смотреть Is Pulse or Continuous Itraconazole Therapy More Effective for Onychomycosis?

Itraconazole, a triazole antifungal with fungistatic activity, is a second-line option for onychomycosis, often used when terbinafine is ineffective or poorly tolerated. Clinical trials report mycologic cure rates of ~60% and clinical improvement rates of ~70% with both pulse and continuous regimens. Pulse therapy involves 200 mg twice daily for 1 week per month, lasting 2 months for fingernails and 3 months for toenails. Continuous therapy requires 200 mg daily for 6–12 weeks. Liver function monitoring is recommended for extended use or preexisting liver conditions. While generally well-tolerated, side effects include headaches, gastrointestinal symptoms, and rare hepatotoxicity. Itraconazole has significant drug interaction risks and is contraindicated in patients with ventricular dysfunction.

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