Neuromuscular Junction Synapse Explained (nicotinic Acetylcholine Receptors) | Clip

Welcome to Science With Tal!

In this clip of the The Neuromuscular Junction as the model of the chemical synapse video, we will cover the mechanism how signal transmission in the neuromuscular junction occurs. More particularly, the video will cover the formation of acetylcholine, how it is released, to what it binds and signal degradation by acetylcholinesterase. There will also be a word about nicotinic acetylcholine receptor and their properties such as subunits, binding sites and its antagonists/agonists.

To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.

Timestamps

0:00 Introduction
0:16 Motivation for NMJ
0:40 Where is the NMJ? & some basic terminology
1:40 Why the NMJ? & some basic terminology
3:30 How acetylcholine is made at the neuromuscular junction
4:44 Transmitter release steps
5:10 Nicotinic acetylcholine receptor properties (subunits, binding sites, agonists and antagonists)
7:30 Postsynaptic response & structural advantages of NMJ
8:35 Degradation of the signal
9:39 Conclusion

Resources used

Here is a list of the resources that I’ve used to produce this video. (Author: title resource)

- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Robertson, J. David: Some Features of the Ultrastructure of Reptilian
Skeletal Muscle
- Heuser, J E et al. : Synaptic vesicle exocytosis captured by quick freezing
and correlated with quantal transmitter release
- Heuser, J E and T S Reese: Evidence for recycling of synaptic vesicle
membrane during transmitter release at the frog neuromuscular junction
- Llinás, R and Y Yarom: Properties and distribution of ionic
conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro
- Katz, B, and R Miledi: A study of synaptic transmission in the
absence of nerve impulses
- BOYD, I A,and A R MARTIN: The end-plate potential in mammalian
muscle
- DEL CASTILLO, J, and B KATZ: Quantal components of the end-plate potential

To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.

Video credits

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - jay (   • lukrembo - jay (royalty free vlog music)  )